苯基和酚类化合物对大鼠肝脏甲羟戊酸焦磷酸脱羧酶和甲羟戊酸磷酸激酶的抑制作用。
Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds.
作者信息
Shama Bhat C, Ramasarma T
出版信息
Biochem J. 1979 Jul 1;181(1):143-51. doi: 10.1042/bj1810143.
Abstract
- Mevalonate pyrophosphate decarboxylase of rat liver is inhibited by various phenyl and phenolic acids. 2. Some of the phenyl and phenolic acids also inhibited mevalonate phosphate kinase. 3. Compounds with the phenyl-vinyl structure were more effective. 4. Kinetic studies showed that some of the phenolic acids compete with the substrates, mevalonate 5-phosphate and mevalonate 5-pyrophosphate, whereas others inhibit umcompetitively. 5. Dihydroxyphenyl and trihydroxyphenyl compounds and p-chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. 6. Of the three mevalonate-metabolizing enzymes, mevalonate pyrophosphate decarboxylase has the lowest specific activity and is probably the rate-determining step in this part of the pathway.
摘要
- 大鼠肝脏的甲羟戊酸焦磷酸脱羧酶受到多种苯基酸和酚酸的抑制。2. 一些苯基酸和酚酸也抑制甲羟戊酸磷酸激酶。3. 具有苯乙烯基结构的化合物更有效。4. 动力学研究表明，一些酚酸与底物甲羟戊酸5-磷酸和甲羟戊酸5-焦磷酸竞争，而其他酚酸则非竞争性抑制。5. 二羟基苯基和三羟基苯基化合物以及对氯苯氧异丁酸（一种降胆固醇药物）对这些酶没有影响。6. 在三种甲羟戊酸代谢酶中，甲羟戊酸焦磷酸脱羧酶的比活性最低，可能是该途径这一部分的限速步骤。
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