妊娠及产后子宫复旧期间小鼠原胶原蛋白脯氨酸羟化酶
Protocollagen proline hydroxylase of the mouse uterus during pregnancy and post-partum involution.
作者信息
Halme J, Jääskeläinen M
出版信息
Biochem J. 1970 Feb;116(3):367-9. doi: 10.1042/bj1160367.
Abstract
- The protocollagen proline hydroxylase in mouse uterus was found to be similar to that in other animal sources in its subcellular distribution and cofactor requirements. 2. The activities of this enzyme in uterine tissue from non-pregnant mice were comparable with those in various embryonic tissues. 3. In the second half of pregnancy the protocollagen proline hydroxylase activity increased markedly. 4. After parturition the activity of this enzyme decreased rapidly, reaching normal non-pregnant values at 24h post partum. The results suggest a good correlation between the synthesis of collagen and the activity of protocollagen proline hydroxylase.
摘要
- 发现小鼠子宫中的原胶原脯氨酸羟化酶在亚细胞分布和辅助因子需求方面与其他动物来源的该酶相似。2. 未孕小鼠子宫组织中这种酶的活性与各种胚胎组织中的活性相当。3. 在妊娠后半期，原胶原脯氨酸羟化酶活性显著增加。4. 分娩后，这种酶的活性迅速下降，在产后24小时达到未孕时的正常水平。结果表明胶原蛋白的合成与原胶原脯氨酸羟化酶的活性之间有良好的相关性。
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