异种核糖核酸对小鼠肿瘤同基因移植免疫的介导作用。
Mediation of immunity to tumor isografts in mice by heterologous ribonucleic acid.
作者信息
Ramming K P, Pilch Y H
出版信息
Science. 1970 Apr 24;168(3930):492-3. doi: 10.1126/science.168.3930.492.
PMID:5436085
Abstract
The growth of tumor isografts in inbred mice is inhibited by intra-peritoneal injections of syngeneic spleen incubated, in vitro, with ribonucleic acid extracted from guinea pigs immunized with the same mouse tumor. This inhibition is partially tumor-specific. Treatment with ribonuclease abolishes the response.
摘要
通过向近交系小鼠腹腔内注射与从用相同小鼠肿瘤免疫的豚鼠提取的核糖核酸在体外共同孵育的同基因脾脏，可抑制小鼠肿瘤同基因移植瘤的生长。这种抑制作用具有部分肿瘤特异性。用核糖核酸酶处理可消除该反应。
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