脆弱拟杆菌对人红细胞膜的影响：Tk多凝集的发病机制。
Effect of Bacteroides fragilis on the human erythrocyte membrane: pathogenesis of Tk polyagglutination.
作者信息
Inglis G, Bird G W, Mitchell A A, Milne G R, Wingham J
出版信息
J Clin Pathol. 1975 Dec;28(12):964-8. doi: 10.1136/jcp.28.12.964.
Abstract
Incubation of normal human erythrocytes with the supernatant of centrifuged culture of some strains of Bacteroides fragilis results in the exposure of Tk polyagglutination determinants on the erythrocyte membrane. These determinants are present on non papain-labile structures and are probably exposed by an enzyme mechanism. Other strains of B. fragilis were found to produce neuraminidase, haemolysins, and protease. It is suggested that early recognition of Tk determinants may be an aid to the diagnosis of B. fragilis infection.
摘要
将正常人红细胞与某些脆弱拟杆菌菌株离心培养的上清液一起孵育，会导致红细胞膜上暴露Tk多凝集决定簇。这些决定簇存在于非木瓜蛋白酶敏感结构上，可能是通过酶机制暴露出来的。还发现其他脆弱拟杆菌菌株可产生神经氨酸酶、溶血素和蛋白酶。有人提出，对Tk决定簇的早期识别可能有助于脆弱拟杆菌感染的诊断。
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