脊椎动物中的葡萄糖利用作为研究进化的分子探针。

Glucose utilization in vertebrates as a molecular probe for the study of evolution.

作者信息

Ureta T, Radojković J, Preller A, Guixé V

出版信息

Arch Biol Med Exp. 1979 Jul;12(1):49-58.

Abstract

Hexokinase isozymic profiles from the liver of 68 vertebrate species are presented. The comparison of the diverse patterns observed, as well as the kinetic and physicochemical properties of the isozymes, reveals that the hexokinases from mammals are very similar to those from turtles and amphibians. The hexokinases from birds, lizards and snakes on the other hand are similar within themselves and different from the enzymes from mammals and amphibians. Liver pyruvate kinases show about the same behavior. The hexokinase system from vertebrate muscle however is very uniform in all the species studied consisting mainly of hexokinase B.

摘要

本文展示了68种脊椎动物肝脏中的己糖激酶同工酶谱。对观察到的不同模式以及同工酶的动力学和物理化学性质进行比较后发现，哺乳动物的己糖激酶与龟类和两栖动物的己糖激酶非常相似。另一方面，鸟类、蜥蜴和蛇类的己糖激酶彼此相似，与哺乳动物和两栖动物的酶不同。肝脏丙酮酸激酶表现出大致相同的情况。然而，在所有研究的物种中，脊椎动物肌肉中的己糖激酶系统非常一致，主要由己糖激酶B组成。