高等动物中己糖激酶对D-葡萄糖异头物的偏好性
D-Glucose anomeric preference of hexokinases in higher animals.
作者信息
Okuda J, Miwa I, Inagaki K, Ueda M, Taketa K
出版信息
J Biochem. 1978 Oct;84(4):993-5.
The D-glucose anomeric preference of hexokinases isolated from rat liver, brain, and skeletal muscle, and bovine retina was studied using the glucose-6-phosphate dehydrogenase-NADP system. The ratios of maximum phosphorylation rates of beta-D-glucose to those of alpha-D-glucose were 1.33, 1.46, and 1.54 for hexokinase types I, II, and III from rat liver, 1.45 and 1.63 for type I from rat brain and bovine retina, 1.53 for type II from rat skeletal muscle, and 0.55 (when determined at 5 mM) for type IV (glucokinase) from rat liver, respectively.
利用葡萄糖-6-磷酸脱氢酶-NADP系统，研究了从大鼠肝脏、大脑、骨骼肌以及牛视网膜中分离出的己糖激酶对D-葡萄糖异头物的偏好性。大鼠肝脏中I型、II型和III型己糖激酶催化β-D-葡萄糖的最大磷酸化速率与α-D-葡萄糖的最大磷酸化速率之比分别为1.33、1.46和1.54；大鼠大脑和牛视网膜中I型己糖激酶的该比值分别为1.45和1.63；大鼠骨骼肌中II型己糖激酶的该比值为1.53；大鼠肝脏中IV型（葡萄糖激酶）己糖激酶的该比值为0.55（在5 mM浓度下测定时）。
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