Harada T, Takahashi H, Kaya H, Inoki R
Arch Int Pharmacodyn Ther. 1979 Dec;242(2):273-84.
Marked depression of locomotor activity was observed in writhing mice given acetic acid i.p. This depression of the activity was evidenced by a squatting posture in reaction to pain. The hypoactivity was reversed dose-dependently by nonnarcotic analgesics such as acetyl-salicylic acid, aminopyrine and mefenamic acid in smaller dosages than those obtained by the conventional writhing syndrome test, and was also reversed dose-dependently by narcotic analgesics such as morphine, pethidine and codeine. Consequently, this hypoactivity test proved to be useful for analgesics screening.
腹腔注射醋酸后，扭体小鼠出现明显的运动活动抑制。这种活动抑制表现为对疼痛反应时的蹲伏姿势。非麻醉性镇痛药如乙酰水杨酸、氨基比林和甲芬那酸，以比传统扭体综合征试验更小的剂量就能剂量依赖性地逆转这种活动减退；麻醉性镇痛药如吗啡、哌替啶和可待因也能剂量依赖性地逆转这种活动减退。因此，这种活动减退试验被证明对镇痛药筛选有用。
