Modai J, Pierre J, Bergogne-Berezin E, Avril M F
Arzneimittelforschung. 1979;29(12a):1967-9.
The passage of 6-[(R)-2-[3-methylsulfonyl-2-oxo-imidazolidine-1-carboxamido]-2-phenyl-acetamido)-penicillanic acid sodium salt (mezlocillin, Baypen), into the CSF was studied in 9 patients with symptoms of acute meningitis, presumed to be of viral origin. The antibiotic was given as a single 5 g dose i.v. over 30 min. The CSF/serum concentration ratio of mezlocillin showed a variation from 0 to 10.7%. The antibiotic could be effective in the treatment of bacterial meningitis caused by ampicillin-resistant strains of Haemophilus influenzae and by most Enterobacteriaceae, provided these results will be confirmed by a study now in progress. In one patient suffering from meningococcal meningitis this concentration ratio varied between 72% (day 3) and 54% (day 12).
在9例疑似病毒感染引起急性脑膜炎症状的患者中，研究了6-[(R)-2-[3-甲基磺酰基-2-氧代-咪唑烷-1-甲酰胺基]-2-苯基-乙酰胺基]-青霉烷酸钠盐（美洛西林，拜朋）进入脑脊液的情况。抗生素以5g单次剂量静脉滴注，30分钟内滴完。美洛西林的脑脊液/血清浓度比在0至10.7%之间变化。如果目前正在进行的一项研究能证实这些结果，那么该抗生素可能对由耐氨苄西林的流感嗜血杆菌菌株和大多数肠杆菌科细菌引起的细菌性脑膜炎有效。在1例患脑膜炎球菌性脑膜炎的患者中，该浓度比在72%（第3天）至54%（第12天）之间变化。
