Vent J
Arzneimittelforschung. 1979;29(12a):1969-71.
20 patients undergoing extended hip surgery received a single i.v. injection of 2 g 6-[(R)-2-[3-methylsulfonyl-2-oxo-imidazolidine-1-carboxamido]-2-phenyl-acetamido]-penicillanic acid sodium salt (mezlocillin, Baypen). At different times after the infections but simultaneously 31 samples of blood and bone (spongiosa) were collected for determination of mezlocillin concentrations. On an average, maximum concentrations of approximately 20 microgram/g bone were demonstrated 30 min after injection, these being within the clinico-therapeutical range. The concentration of azlocillin--another acylureido-penicillin--was comparatively higher.
20例接受髋关节扩大手术的患者接受了一次静脉注射2克6-[(R)-2-[3-甲基磺酰基-2-氧代-咪唑烷-1-甲酰胺基]-2-苯基-乙酰胺基]-青霉烷酸钠盐（美洛西林，拜朋）。在感染后的不同时间，但同时采集了31份血液和骨（松质骨）样本，用于测定美洛西林浓度。平均而言，注射后30分钟骨中显示出约20微克/克的最大浓度，这些浓度处于临床治疗范围内。阿洛西林（另一种酰脲基青霉素）的浓度相对较高。
