Soares L A, Trabulsi L R
Arzneimittelforschung. 1979;29(12a):1932-4.
The antimicrobial activity of 6-[(R)-2[3-methylsulfonyl-2-oxo-imidazolidine-1-carboxamido]-2-phenylacetamido]-penicillanic acid sodium salt (mezlocillin, Baypen) and 6-[(R)-2-(2-oxo-imidazolidine-1-carboxamido)-2-phenylacetamido-a1-penicillanic acid sodium salt (azlocillin, Securopen) was measured against 545 clinical isolates, including gram-negative rods, gram-positive cocci and Bacteroides. Mezlocillin was more effective than azlocillin against the majority of the strains studied, but azlocillin was more effective against Pseudomonas strains. The minimal bactericidal concentration was equal to the minimal inhibitory concentration for the strains tested, but it was twice or four-fold as high for Staphylococcus.
测定了6-[(R)-2[3-甲基磺酰基-2-氧代-咪唑烷-1-甲酰胺基]-2-苯乙酰胺基]-青霉烷酸钠盐（美洛西林，拜朋）和6-[(R)-2-(2-氧代-咪唑烷-1-甲酰胺基)-2-苯乙酰胺基-a1-青霉烷酸钠盐（阿洛西林，塞库罗朋）对545株临床分离菌的抗菌活性，这些分离菌包括革兰氏阴性杆菌、革兰氏阳性球菌和拟杆菌。在大多数所研究的菌株中，美洛西林比阿洛西林更有效，但阿洛西林对假单胞菌属菌株更有效。对于所测试的菌株，最小杀菌浓度等于最小抑菌浓度，但对葡萄球菌而言，最小杀菌浓度是其两倍或四倍。
