Alfthan O, Renkonen O V, Ohlsson H
Arzneimittelforschung. 1979;29(12a):1979-81.
20 patients, aged 18-84 years, with complicated urinary tract infections admitted to hospital were treated with 6-[(R)-2-(2-oxo-imidazolidine-1-carboxamido)-2-phenyl-acetamido]-penicillanic acid sodium salt (azlocillin, Securopen) for 5 to 10 days. Isolated bacteria were Pseudomonas aeruginosa (14), Proteus mirabilis (3), Escherichia coli (2) and Klebsiella spp. (1). Serum concentrations and urine recovery were measured on the fifth day of treatment. The mean serum half-life was 1.85 h and the mean value of the urine recovery 47% of the single dose. Tissue concentrations were analyzed in one patient. The samples were taken 3 h after the infusion. The azlocillin concentration of the renal cortex, 60 microgram/g, was six times higher than the corresponding serum concentration. On the 5th day of treatment the urine was sterile in 80% of the patients. In 12 patients (60%) the urine was still sterile when controlled 2-6 months later. Three patients were treated twice and bacteriologically cured after each period. No sign of sensitization was seen. Side-effects were not reported.
20例年龄在18 - 84岁之间、因复杂性尿路感染入院的患者，接受了6 - [(R)-2-(2-氧代-咪唑烷-1-甲酰胺基)-2-苯基-乙酰胺基]-青霉烷酸钠盐（阿洛西林，舒普深）治疗5至10天。分离出的细菌有铜绿假单胞菌（14例）、奇异变形杆菌（3例）、大肠杆菌（2例）和克雷伯菌属（1例）。在治疗的第五天测量血清浓度和尿液回收率。平均血清半衰期为1.85小时，尿液回收率的平均值为单剂量的47%。对1例患者的组织浓度进行了分析。在输注后3小时采集样本。肾皮质的阿洛西林浓度为60微克/克，比相应的血清浓度高6倍。治疗第5天时，80%的患者尿液无菌。在2 - 6个月后复查时，12例患者（60%）尿液仍无菌。3例患者接受了两次治疗，每个疗程后细菌学治愈。未观察到致敏迹象。未报告有副作用。
