Alfthan O, Renkonen O V, Ohlsson H
Scand J Infect Dis Suppl. 1981;29:98-101.
Eighteen patients, aged 18-84 years, with complicated urinary tract infections admitted to hospital were treated preoperatively with azlocillin (Securopen) for 5 to 10 days. Two patients having chronic pyelonephritis were not operated. Isolates bacteria were Pseudomonas aeruginosa (14), Proteus mirabilis (3), Escherichia coli (2) and Klebsiella spp. (1). Serum concentrations and urine recovery were measured on the fifth day of treatment. The mean serum half-life was 1.85 h and the mean value of the urine recovery 47% of the single dose. On the 5th day of treatment the urine was sterile in 80% of the patients. In 12 patients (60%) the urine was still sterile when controlled 2-6 months after operation and prophylactic postoperative treatment with nitrofurantoin or trimethoprim-sulfamethoxazole.
18例年龄在18 - 84岁之间、因复杂性尿路感染入院的患者在术前接受了阿洛西林（舒氨西林）治疗5至10天。2例患有慢性肾盂肾炎的患者未接受手术。分离出的细菌有铜绿假单胞菌（14例）、奇异变形杆菌（3例）、大肠埃希菌（2例）和克雷伯菌属（1例）。在治疗的第5天测量血清浓度和尿液回收率。平均血清半衰期为1.85小时，尿液回收率的平均值为单剂量的47%。在治疗的第5天，80%的患者尿液无菌。12例患者（60%）在术后2 - 6个月进行复查时尿液仍无菌，术后用呋喃妥因或甲氧苄啶 - 磺胺甲恶唑进行预防性治疗。
