Ayliffe G A
J Clin Pathol. 1970 Feb;23(1):19-23. doi: 10.1136/jcp.23.1.19.
A strain of Staphylococcus aureus isolated from the skin of a subject with eczema showed a loss in resistance to neomycin and tetracycline after treatment with neomycin was stopped. Seven out of 22 strains of neomycin-resistant Staph. aureus showed a loss in resistance to neomycin and streptomycin after storage in nutrient broth for 14 days at room temperature, and it seems probable that resistance in these unstable strains was controlled by extrachromosomal elements or plasmids. Strains of phage types 84/85 and 29/77 and related types were frequently isolated in general hospital wards and showed no loss in resistance on similar storage in nutrient broth. Five of the neomycin-unstable strains were isolated from patients with eczematous lesions. Multiple-resistant and antibiotic-sensitive strains of Staph. aureus of similar phage type were isolated from patients in a ward for patients with skin disease, and the possibility of transfer of resistance in vivo is discussed.
从一名湿疹患者皮肤分离出的一株金黄色葡萄球菌，在停止使用新霉素治疗后，对新霉素和四环素的耐药性丧失。22株耐新霉素的金黄色葡萄球菌中有7株在室温下于营养肉汤中保存14天后，对新霉素和链霉素的耐药性丧失，这些不稳定菌株的耐药性似乎很可能由染色体外元件或质粒控制。84/85和29/77噬菌体类型及相关类型的菌株在综合医院病房中经常分离到，在营养肉汤中进行类似保存时未出现耐药性丧失。5株新霉素不稳定菌株是从患有湿疹性病变的患者中分离出来的。在一个皮肤病患者病房中，从患者身上分离出了具有相似噬菌体类型的多重耐药和抗生素敏感的金黄色葡萄球菌菌株，并讨论了体内耐药性转移的可能性。
