Roberts G, Anderson A, McGarry J, Turnbull A C
Br Med J. 1970 Apr 18;2(5702):152-4. doi: 10.1136/bmj.2.5702.152.
Water diuresis was induced in six patients in mid-pregnancy. Three were then given oxytocin and the remainder prostaglandin F(2)alpha (PGF(2)alpha), both drugs being infused intravenously in doses used to induce labour at term. Pronounced antidiuresis occurred with oxytocin, whereas PGF(2)alpha showed no such effect. The probable absence of any risk of water intoxication when using PGF(2)alpha in inducing labour may be of particular value when maternal pre-eclampsia or renal disease is present.
对6名孕中期妇女进行了水利尿试验。其中3名随后给予催产素，其余给予前列腺素F(2)α（PGF(2)α），两种药物均采用足月引产时使用的剂量静脉输注。催产素导致明显的抗利尿作用，而PGF(2)α则无此作用。在引产时使用PGF(2)α时可能不存在水中毒风险，这在存在母体先兆子痫或肾脏疾病时可能具有特别的价值。
