洋地黄毒苷元和地高辛配基作为其环氧基酸甲酯醋酸酯的气液色谱分析
Gas-liquid chromatography of digitoxigenin and digoxigenin as acetates of their epoxygeninic acid methyl esters.
作者信息
Meilink J W, Lenstra J B, Svendsen A B
出版信息
J Chromatogr. 1979 Feb 11;170(1):35-41. doi: 10.1016/s0021-9673(00)84235-1.
PMID:544629
Abstract
Gas chromatographic analysis of ditigoxigenin and digoxigenin, the genins of the cardenolide glycosides digitoxin and digoxin, cannot be done without derivatization. However, during the derivatization, side-reactions often present serious problems. A procedure has been found for transforming digitoxigenin and digoxigenin into the corresponding acetates of their epoxygeninic acid methyl esters, which are stable compounds and suitable for gas chromatographic analysis.
摘要
洋地黄毒苷元和地高辛配基（强心苷类化合物洋地黄毒苷和地高辛的苷元）不经衍生化处理无法进行气相色谱分析。然而，在衍生化过程中，副反应常常会带来严重问题。现已发现一种方法，可将洋地黄毒苷元和地高辛配基转化为它们的环氧次甲基酸甲酯的相应乙酸酯，这些都是稳定的化合物，适合进行气相色谱分析。
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