Powell L W, Jacobi J M, Gaffney T J, Adam R
Br Med J. 1970 Jul 25;3(5716):194-5. doi: 10.1136/bmj.3.5716.194.
Medroxyprogesterone acetate, a pure progestational agent which is not metabolized to oestrogen, was given to 30 women and shown to have no effect on the serum levels of iron, total iron-binding capacity, transferrin, and protein-bound iodine. Eighteen of these women had previously taken oral contraceptives of the combined oestrogen-progestogen "sequential" type, and during that time these serum levels were raised. Nevertheless, the levels all fell significantly after medroxyprogesterone acetate was given and the "sequential" oral contraceptive was stopped. In a further 12 postpartum women the serum levels did not change significantly after medroxyprogesterone acetate.These observations strongly suggest that raised plasma protein levels resulting from the administration of oral contraceptives are due to the oestrogen component.
醋酸甲羟孕酮是一种不会代谢为雌激素的纯孕激素，对30名女性进行给药后发现，它对血清铁、总铁结合力、转铁蛋白和蛋白结合碘水平没有影响。其中18名女性此前服用过雌激素 - 孕激素联合“序贯”型口服避孕药，在此期间这些血清水平有所升高。然而，在给予醋酸甲羟孕酮并停用“序贯”口服避孕药后，这些水平均显著下降。在另外12名产后女性中，给予醋酸甲羟孕酮后血清水平没有明显变化。这些观察结果有力地表明，口服避孕药导致的血浆蛋白水平升高是由雌激素成分引起的。
