头孢菌素的分子结构。基于结构研究对生物活性的见解。 - Suppr

Suppr

超能文献

Molecular architecture of the cephalosporins. Insights into biological activity based on structural investigations.

作者信息

Sweet R M, Dahl L F

出版信息

J Am Chem Soc. 1970 Sep 9;92(18):5489-507. doi: 10.1021/ja00721a032.

DOI:10.1021/ja00721a032

PMID:5449447

Abstract

摘要

相似文献

Molecular architecture of the cephalosporins. Insights into biological activity based on structural investigations.头孢菌素的分子结构。基于结构研究对生物活性的见解。

J Am Chem Soc. 1970 Sep 9;92(18):5489-507. doi: 10.1021/ja00721a032.

Structural insights into substrate recognition and product expulsion in CTX-M enzymes.CTX-M 酶中底物识别和产物排出的结构见解。

J Mol Biol. 2010 Jul 2;400(1):108-20. doi: 10.1016/j.jmb.2010.04.062. Epub 2010 May 7.

Penicillin target enzyme and the antibiotic binding site.青霉素作用的靶酶及抗生素结合位点。

Science. 1982 Oct 29;218(4571):479-81. doi: 10.1126/science.7123246.

The structure of cephaloridine hydrochloride monohydrate.盐酸头孢噻啶一水合物的结构。

Biochem Biophys Res Commun. 1969 Jan 6;34(1):14-6. doi: 10.1016/0006-291x(69)90520-8.

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins.NDM-1 催化头孢菌素水解的结构和机制见解。

J Am Chem Soc. 2014 Oct 22;136(42):14694-7. doi: 10.1021/ja508388e. Epub 2014 Oct 7.

An engineered disulfide bond between residues 69 and 238 in extended-spectrum beta-lactamase Toho-1 reduces its activity toward third-generation cephalosporins.超广谱β-内酰胺酶Toho-1中69位和238位残基之间的一个工程化二硫键降低了其对第三代头孢菌素的活性。

Biochemistry. 2004 Dec 21;43(50):15737-45. doi: 10.1021/bi048488u.

Theoretical studies on beta-lactam antibiotics. I. Conformational similarity of penicillins and cephalosporins to X-D-alanyl-D-alanine and correlation of their structure with activity.β-内酰胺抗生素的理论研究。I. 青霉素和头孢菌素与X-D-丙氨酰-D-丙氨酸的构象相似性及其结构与活性的相关性。

Int J Pept Protein Res. 1977;10(1):51-9.

Metallo-β-lactamase-catalyzed hydrolysis of cephalosporins: some mechanistic insights into the effect of heterocyclic thiones on enzyme activity.金属β-内酰胺酶催化头孢菌素的水解：杂环硫酮对酶活性影响的一些机理见解。

Inorg Chem. 2011 Feb 7;50(3):749-56. doi: 10.1021/ic100253k. Epub 2011 Jan 6.

Crystal structure of EstSRT1, a family VIII carboxylesterase displaying hydrolytic activity toward oxyimino cephalosporins.EstSRT1的晶体结构，一种对氧亚氨基头孢菌素具有水解活性的VIII族羧酸酯酶。

Biochem Biophys Res Commun. 2016 Sep 16;478(2):818-24. doi: 10.1016/j.bbrc.2016.08.031. Epub 2016 Aug 5.

[Structure-activity relationship of cephalosporins. II. Effect of oxygen-containing functional groups on the biological activity od cephalosporins--derivatives of 7-aminocephalosporanic acid].[头孢菌素的构效关系。II. 含氧化官能团对头孢菌素生物活性的影响——7-氨基头孢烷酸的衍生物]

Antibiot Khimioter. 1991 Apr;36(4):12-5.

引用本文的文献

The Chemical Relationship Among Beta-Lactam Antibiotics and Potential Impacts on Reactivity and Decomposition.β-内酰胺类抗生素之间的化学关系及其对反应活性和分解的潜在影响。

Front Microbiol. 2022 Mar 24;13:807955. doi: 10.3389/fmicb.2022.807955. eCollection 2022.

Delta 2- and delta 3-cephalosporins, penicillinate and 6-unsubstituted penems. Intrinsic reactivity and interaction with beta-lactamases and D-alanyl-D-alanine-cleaving serine peptidases.δ2-和δ3-头孢菌素、青霉素酸盐及6-未取代青霉烯。内在反应活性以及与β-内酰胺酶和D-丙氨酰-D-丙氨酸裂解丝氨酸肽酶的相互作用。

Biochem J. 1982 Apr 1;203(1):223-34. doi: 10.1042/bj2030223.

Stereochemistry of the incorporation of valine methyl groups into methylene groups in cephalosporin C.缬氨酸甲基基团掺入头孢菌素C中亚甲基基团的立体化学

Biochem J. 1984 Sep 15;222(3):777-88. doi: 10.1042/bj2220777.

Correlation between the binding of beta-lactam antibiotics to Staphylococcus aureus and their physical-chemical properties.β-内酰胺类抗生素与金黄色葡萄球菌的结合与其物理化学性质之间的相关性。

Antimicrob Agents Chemother. 1972 Sep;2(3):173-80. doi: 10.1128/AAC.2.3.173.

Solid-state chemistry and crystal structure of cefaclor dihydrate.头孢克洛二水合物的固态化学与晶体结构

Pharm Res. 1990 Feb;7(2):147-53. doi: 10.1023/a:1015824701581.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验