MacDougall A I, Addis G J, MacKay N, Dymock I W, Turpie A G, Ballingall D L, MacLennan W J, Whiting B, MacArthur J G
Br Med J. 1970 Aug 22;3(5720):440-2. doi: 10.1136/bmj.3.5720.440.
Clonidine, in a daily dosage of 0.15-4.8 mg., effectively lowered systolic and diastolic pressures in 26 out of 28 impatients with moderate to severe hypertension, including five with primary renal disease. The action of the drug did not depend on posture and was not associated with reduction in renal function. Side-effects were not severe, but mental changes occurred in four patients.Clonidine is a useful alternative to currently available antihypertensive drugs, but further evaluation of its longterm efficacy is required.
可乐定，每日剂量为0.15 - 4.8毫克，在28例中重度高血压患者（包括5例原发性肾病患者）中有26例患者的收缩压和舒张压得到有效降低。该药的作用不取决于体位，且与肾功能减退无关。副作用并不严重，但有4例患者出现精神改变。可乐定是现有抗高血压药物的一种有用替代药物，但需要对其长期疗效进行进一步评估。
