可乐定治疗高血压
Treatment of hypertension with clonidine.
作者信息
MacDougall A I, Addis G J, MacKay N, Dymock I W, Turpie A G, Ballingall D L, MacLennan W J, Whiting B, MacArthur J G
出版信息
Br Med J. 1970 Aug 22;3(5720):440-2. doi: 10.1136/bmj.3.5720.440.
Abstract
Clonidine, in a daily dosage of 0.15-4.8 mg., effectively lowered systolic and diastolic pressures in 26 out of 28 impatients with moderate to severe hypertension, including five with primary renal disease. The action of the drug did not depend on posture and was not associated with reduction in renal function. Side-effects were not severe, but mental changes occurred in four patients.Clonidine is a useful alternative to currently available antihypertensive drugs, but further evaluation of its longterm efficacy is required.
摘要
可乐定，每日剂量为0.15 - 4.8毫克，在28例中重度高血压患者（包括5例原发性肾病患者）中有26例患者的收缩压和舒张压得到有效降低。该药的作用不取决于体位，且与肾功能减退无关。副作用并不严重，但有4例患者出现精神改变。可乐定是现有抗高血压药物的一种有用替代药物，但需要对其长期疗效进行进一步评估。
相似文献
1
Treatment of hypertension with clonidine.可乐定治疗高血压
Br Med J. 1970 Aug 22;3(5720):440-2. doi: 10.1136/bmj.3.5720.440.
2
[Water-sodium depletion and clonidine in severe arterial hypertension].[重度动脉高血压中的水钠耗竭与可乐定]
Maroc Med. 1972 Apr;52(556):187-92.
3
The treatment of benign hypertension with clonidine.可乐定治疗良性高血压。
Scott Med J. 1970 Apr;15(4):137-42. doi: 10.1177/003693307001500403.
4
[Behavior of hemodynamic values of patients with hypertension during dichlorphenylamino-imidazoline therapy].[二氯苯氨基咪唑啉治疗高血压患者时血流动力学值的变化]
Wien Klin Wochenschr. 1969 Mar 14;81(11):187-92.
5
Antihypertensive effect of a new imidazoline compound (clonidine) and chlorthalidone, individually and in combination.
Am J Cardiol. 1970 Sep;26(3):258-61. doi: 10.1016/0002-9149(70)90792-7.
6
Hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone in treatment of hypertension.可乐定-氢氯噻嗪和甲基多巴-氢氯噻嗪治疗高血压的降压作用及副作用。
Br Med J. 1970 Nov 14;4(5732):392-5. doi: 10.1136/bmj.4.5732.392.
7
[Use of St 155 in chronic renal insufficiency with arterial hypertension].[St 155在伴有动脉高血压的慢性肾功能不全中的应用]
Prensa Med Argent. 1971 Jul;58(22):1117-9.
8
[New chemotherapy in arterial hypertension].[动脉高血压的新型化疗方法]
Minerva Med. 1971 Nov 7;62(84):4143-8.
9
10
Antihypertensive efficacy and safety of olmesartan and ramipril in elderly patients with mild to moderate systolic and diastolic essential hypertension.奥美沙坦与雷米普利治疗老年轻至中度收缩期和舒张期原发性高血压的降压疗效及安全性
Blood Press Suppl. 2011 Apr;1:3-11. doi: 10.3109/08037051.2010.532332. Epub 2010 Nov 23.
引用本文的文献
1
Identification of Catecholamine and Drug Target α-Adrenoceptor in Human Testis and Human Testicular Peritubular Cells.人睾丸及人睾丸周细胞中儿茶酚胺和药物靶点α-肾上腺素能受体的鉴定
J Clin Med. 2024 Jul 25;13(15):4357. doi: 10.3390/jcm13154357.
2
Current and Emerging Classes of Pharmacological Agents for the Management of Hypertension.目前和新兴的高血压管理药物类别。
Am J Cardiovasc Drugs. 2022 May;22(3):271-285. doi: 10.1007/s40256-021-00510-9. Epub 2021 Dec 8.
3
Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine.聚焦淋巴途径以优化心血管医学中的药物递送
Pharmaceutics. 2021 Aug 4;13(8):1200. doi: 10.3390/pharmaceutics13081200.
4
Is Mania the Hypertension of the Mood? Discussion of A Hypothesis.躁狂是情绪的“高血压”吗？关于一种假说的探讨。
Curr Neuropharmacol. 2017 Apr;15(3):424-433. doi: 10.2174/1570159X14666160902145635.
5
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.去甲肾上腺素能蓝斑核的功能神经解剖学：其在觉醒和自主功能调节中的作用 第二部分：人类蓝斑核活动的生理和药理学操作及病理性改变。
Curr Neuropharmacol. 2008 Sep;6(3):254-85. doi: 10.2174/157015908785777193.
6
Treatment of severe hypertension and hypertensive emergencies with intravenous clonidine hydrochloride.静脉注射盐酸可乐定治疗重度高血压和高血压急症。
Postgrad Med J. 1973 Dec;49(578):908-13. doi: 10.1136/pgmj.49.578.908.
7
The Glasgow blood pressure clinic.格拉斯哥血压诊所。
J R Coll Physicians Lond. 1972 Oct;7(1):87-97.
8
Drug-induced psychiatric disorders and their management.药物性精神障碍及其管理。
Med Toxicol. 1986 Nov-Dec;1(6):428-48. doi: 10.1007/BF03259854.
9
A comparative trial of clonidine, propranolol and placebo in the treatment of moderate hypertension.可乐定、普萘洛尔与安慰剂治疗中度高血压的比较试验。
Br J Clin Pharmacol. 1977 Jun;4(3):289-94. doi: 10.1111/j.1365-2125.1977.tb00714.x.
本文引用的文献
1
[Critical considerations on the method of action of 2-(2,6-dichlorophenylamino)-2-imidazoline-hydrochloride].[关于2-(2,6-二氯苯基氨基)-2-咪唑啉盐酸盐作用方式的关键考量]
Arzneimittelforschung. 1966 Aug;16(8):1055-8.
2
[Clinical experiences with a new antihypertensive agent].[一种新型抗高血压药物的临床经验]
Arzneimittelforschung. 1966 Dec;16(12):1610-5.
3
[Clinical and experimental study with the new blood pressure depressant 2-(2,6-dichlorphenylamino)-2-imidazole-hydrochloride].新型降压药2-(2,6-二氯苯基氨基)-2-咪唑盐酸盐的临床与实验研究
Arzneimittelforschung. 1966 Sep;16(9):1174-9.
4
[The effect of an imidazole derivative on arterial blood pressure, hemodynamics and ventilation].
Arzneimittelforschung. 1966 Sep;16(9):1154-60.
5
[Clinical and clinical-experimental studies with a new blood pressure lowering substance: dichlorophenylaminoimidazoline].[一种新型降压物质：二氯苯基氨基咪唑啉的临床及临床实验研究]
Dtsch Med Wochenschr. 1966 Oct 7;91(40):1761-70. doi: 10.1055/s-0028-1111588.
6
[Therapeutic examination and studies on renal function with a new antihypertensive agent (St 155)].[新型抗高血压药物（St 155）对肾功能的治疗性检查与研究]
Dtsch Med Wochenschr. 1966 Sep 23;91(38):1680-6. doi: 10.1055/s-0028-1111574.
7
[First observations on an antihypertensive effect of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride in man].[2-(2,6-二氯苯基氨基)-2-咪唑啉盐酸盐对人体降压作用的首次观察]
Dtsch Med Wochenschr. 1966 Sep 2;91(35):1540-7. doi: 10.1055/s-0028-1111550.
8
Clinical observations on a new antihypertensive drug, 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride.新型抗高血压药物2-（2,6-二氯苯胺）-2-咪唑啉盐酸盐的临床观察
Am Heart J. 1969 Apr;77(4):473-8. doi: 10.1016/0002-8703(69)90156-2.
9
The use of "Catapres" in the treatment of severe hypertension.
Med J Aust. 1969 Oct 4;2(14):684-7. doi: 10.5694/j.1326-5377.1969.tb107345.x.
10
Pharmacodynamic effects of a new antihypertensive drug, Catapres (ST-155).
Circulation. 1969 Feb;39(2):219-28. doi: 10.1161/01.cir.39.2.219.
Zotero 插件