Jennings G, Jones M S, Besterman E M, Model D G, Turner P P, Kidner P H
Lancet. 1976 Jan 10;1(7950):51-4. doi: 10.1016/s0140-6736(76)90148-3.
Oral disopyramide given prophylactically following myocardial infarction has been compared with placebo in a double-blind trial using continuous-tape monoriting of the electocardiogram. It caused a significant reduction in the incidence of ventricular arrhythmias and of the various degrees of heart-block. There was a significant reduction of reinfarction during hospital stay in patients who had received disopyramide. Disopyramide appears to be a safe and effective oral therapy in the prevention of potentially serious arrhythmias following myocardial infarction.
