Nicholson W J, Martin C E, Gracey J G, Knoch H R
Am J Cardiol. 1979 May;43(5):1053-5. doi: 10.1016/0002-9149(79)90374-6.
Three cases are described with documented ventricular fibrillation shortly after the patients received disopyramide in moderate dosage. Electrocardiograms showed markedly prolonged Q-T intervals in two patients and a prominent U wave with a prolonged Q-U interval in one patient, but no change in QRS width. Disopyramide-induced ventricular fibrillation appears to be similar to that caused by quinidine and is an indication to discontinue the drug.
本文描述了3例患者在接受中等剂量丙吡胺后不久记录到心室颤动的病例。心电图显示，2例患者的Q-T间期明显延长，1例患者出现明显的U波且Q-U间期延长，但QRS波宽度无变化。丙吡胺诱发的心室颤动似乎与奎尼丁所致者相似，这是停用该药的指征。
