Howard R O
Trans Am Ophthalmol Soc. 1979;77:121-32.
Generalized lentigo (leopard syndrome) is an autosomal dominant trait characterized by lentigo, sensorineural deafness, retarded growth (below 25%), ocular hypertelorism, mandibular prognathism, pectus carinatum or excavatum, dorsal kyphosis, winging of the scapulae, valvular pulmonary artery stenosis, electrocardiographic conduction defects, and genitourinary defects. Ocular evaluations of patients with generalized lentigo have revealed the appearance of multiple small white punctate and comma-shaped opacities in the cortex and nuclci of the lenses of affected patients. On the basis of age of the patients examined, it would seem that the corneal opacities first appear in the third decade. Although the opacities may be extensive, the lens opacities do not appear to impair visual function until approximately twenty years after they first appear.
泛发性雀斑样痣（豹皮综合征）是一种常染色体显性性状，其特征为雀斑样痣、感音神经性耳聋、生长发育迟缓（低于25%）、眼距增宽、下颌前突、鸡胸或漏斗胸、脊柱后凸、肩胛翼状突出、肺动脉瓣狭窄、心电图传导缺陷以及泌尿生殖系统缺陷。对泛发性雀斑样痣患者的眼部评估显示，受累患者晶状体的皮质和核内出现多个小的白色点状和逗号状混浊。根据所检查患者的年龄，角膜混浊似乎最早出现在第三个十年。尽管混浊可能广泛存在，但晶状体混浊在首次出现后约二十年才似乎会损害视觉功能。
