Georgieva D, Bankov D, Veselinova A
Vet Med Nauki. 1979;16(6):27-34.
The chemico-therapeutical activity of albendasol was studied on 45 guinea-pigs experimentally invaded by 500 muscle trichinellae. The experimental animals were treated with the preparation on the 30th, 60th and 90th day post invasion. At the 10 mg/kg dose a 96.4% effectiveness against 30 day muscle trichinellae, 95.2% against the 60 day, and 81.2% against the 90 day trichinellae was scored, while at 20 mg/kg dose the effectiveness of the treatment was respectively 97.1, 96.3 and 88.6%. Pathomorphological and enzyme (alkaline and acid phosphatase) changes indicate that albendasol probably inactivates the inflammatory protective mechanism of the microorganism and directly participates in the parasite's cell metabolism.
在45只经500条旋毛虫幼虫实验性感染的豚鼠身上研究了阿苯达唑的化学治疗活性。实验动物在感染后第30天、60天和90天用该制剂进行治疗。在10毫克/千克剂量时，对感染30天的肌肉旋毛虫的有效率为96.4%，对感染60天的为95.2%，对感染90天的为81.2%，而在20毫克/千克剂量时，治疗有效率分别为97.1%、96.3%和88.6%。病理形态学和酶（碱性和酸性磷酸酶）变化表明，阿苯达唑可能使微生物的炎症保护机制失活，并直接参与寄生虫的细胞代谢。
