Popova S, Virgieva T, Atanasova J, Atanasov A, Sahatchiev B
Acta Anaesthesiol Scand. 1979 Dec;23(6):505-12. doi: 10.1111/j.1399-6576.1979.tb01480.x.
The effect of 9 ppm halothane, a subanesthetic concentration, was studied on the reproductive ability and pregnancy outcome in white rats. Pregnant females were exposed for 4 h per day during the whole gestation period. Male animals were subjected to halothane inhalation for 4 h daily, 5 days per week for 6 or 8 months. In the exposed females higher rates were established for early interruption of pregnancy (all implants dead) and for embryonic death in the later periods of intrauterine life compared to controls. Deciduomata were found in 22.22% (P less than 0.05) of pregnant treated females. Control females mated to exposed males showed a higher incidence of preimplantation loss (36.36% (P less than 0.05) of those mated with males exposed for 6 months had deciduomata). Decreased fertility in males, expressed particularly in the 8-month treated group, was also demonstrated (13.33% inseminated females, compared to 35% in the control group).
研究了亚麻醉浓度的9 ppm氟烷对白鼠生殖能力和妊娠结局的影响。在整个妊娠期，怀孕雌性每天暴露于氟烷4小时。雄性动物每周5天、每天吸入氟烷4小时，持续6或8个月。与对照组相比，暴露组雌性在妊娠早期中断（所有植入物死亡）和子宫内后期胚胎死亡的发生率更高。在22.22%（P<0.05）接受治疗的怀孕雌性中发现了蜕膜。与暴露雄性交配的对照雌性显示着床前损失的发生率更高（与暴露6个月的雄性交配的雌性中，36.36%（P<0.05）有蜕膜）。还证实了雄性生育力下降，在8个月治疗组中表现尤为明显（受孕雌性为13.33%，对照组为35%）。
