Huovinen K, Lehtovirta P, Forss M, Kivalo I, Teramo K
Acta Anaesthesiol Scand. 1979 Dec;23(6):529-33. doi: 10.1111/j.1399-6576.1979.tb01483.x.
The effect of lumbar epidural block on placental intervillous blood flow (IBF) was estimated with the i.v. 133Xe method in 24 cases and in 14 controls. All parturients had uneventful pregnancies and were scheduled for elective caesarean section. Lumbar epidural block caused a significant decrease in maternal mean arterial pressure (MAP), when no preloading infusion with a plasma expander was given. In contrast, the MAP remained unchanged during lumbar epidural block when the parturients received a preloading infusion (Haemaccel, 100 ml/10 kg body weight within 10 min immediately before lumbar epidural block). The IBF decreased to some extent in the non-preloaded group, but increased temporarily in the preloaded group 15 min after the administration of lumbar epidural block. The mean changes of IBF in the non-preloaded and the preloaded groups differed statistically significantly from each other during lumbar epidural block. The IBF of the preloaded group did not differ significantly from the IBF of the control group receiving no lumbar epidural block.
采用静脉注射¹³³Xe法，对24例产妇及14例对照者进行研究，评估腰段硬膜外阻滞对胎盘绒毛间隙血流（IBF）的影响。所有产妇孕期平顺，均计划行择期剖宫产。在未给予血浆扩容剂预负荷输注时，腰段硬膜外阻滞可导致产妇平均动脉压（MAP）显著下降。相比之下，当产妇接受预负荷输注（在腰段硬膜外阻滞前10分钟内，按100 ml/10 kg体重输注贺斯）时，腰段硬膜外阻滞期间MAP保持不变。在未预负荷组，IBF有一定程度下降，但在腰段硬膜外阻滞给药15分钟后，预负荷组的IBF暂时升高。在腰段硬膜外阻滞期间，未预负荷组和预负荷组IBF的平均变化差异有统计学意义。预负荷组的IBF与未接受腰段硬膜外阻滞的对照组相比，差异无统计学意义。
