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The synthesis of (1-deamino,4-L-leucine)-oxytocin and (1-deamino,4-L-isoleucine)-oxytocin and some of their pharmacological properties.

作者信息

Takashima H, Hruby V J, Du Vigneaud V

出版信息

J Am Chem Soc. 1970 Feb 11;92(3):677-80. doi: 10.1021/ja00706a041.

DOI:10.1021/ja00706a041
PMID:5460748
Abstract
摘要

相似文献

1
The synthesis of (1-deamino,4-L-leucine)-oxytocin and (1-deamino,4-L-isoleucine)-oxytocin and some of their pharmacological properties.
J Am Chem Soc. 1970 Feb 11;92(3):677-80. doi: 10.1021/ja00706a041.
2
The synthesis and some of the pharmacological properties of [4-L-isoleucine]-oxytocin and [4-L-leucine]-oxytocin.
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The synthesis and some pharmacological activities of[4-L-norvaline]-oxytocin and [4-L-norleucine]-oxytocin and their deamino analogs.
J Med Chem. 1969 Nov;12(6):1035-8. doi: 10.1021/jm00306a016.
4
Crystalline deamino-dicarba-oxytocin. Preparation and some pharmacological properties.
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[Synthesis and some pharmacological activities of [2-L-valine]-oxytocin and [2-L-leucine]-oxytocin.[2-L-缬氨酸]-催产素和[2-L-亮氨酸]-催产素的合成及其某些药理活性
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Syntheses and pharmacological properties of selenium isologs of oxytocin and deamino-oxytocin.
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7
Solid-phase synthesis of (2-isoleucine, 4-leucine) oxytocin and (2-phenylalanine, 4-leucine) oxytocin and some their pharmacological properties.（2-异亮氨酸，4-亮氨酸）催产素和（2-苯丙氨酸，4-亮氨酸）催产素的固相合成及其某些药理特性
J Med Chem. 1973 Jun;16(6):624-9. doi: 10.1021/jm00264a010.
8
Solid-phase synthesis of (4-threonine)-oxytocin. A more potent and specific oxytocic agent than oxytocin.（4-苏氨酸）-催产素的固相合成。一种比催产素更有效且更具特异性的催产剂。
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9
Effect of an amide group in place of the disulfide bridge in deamino-oxytocin.脱氨基催产素中酰胺基团取代二硫键的效果。
J Med Chem. 1972 Oct;15(10):1017-9. doi: 10.1021/jm00280a005.
10
4-Threonine analogues of neurohypophysial hormones withh selectively enhanced oxytocin-like activities.
J Endocrinol. 1971 Jan;49(1):151-65. doi: 10.1677/joe.0.0490151.

引用本文的文献

1
The deamino derivatives of (4-threonine)-oxytocin and (4-threonine)-mesotocin; analogs possessing a surprising spectrum of diminished pharmacological activities.（4-苏氨酸）-催产素和（4-苏氨酸）-中催产素的脱氨基衍生物；具有一系列令人惊讶的药理学活性降低的类似物。
Experientia. 1971;27(11):1372-4. doi: 10.1007/BF02136746.
2
Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism.催产素和（1-青霉胺）-催产素中的相对构象刚性：关于构象灵活性与肽类激素激动作用和拮抗作用关系的一项提议。
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1373-7. doi: 10.1073/pnas.74.4.1373.