Golovenko N Ia, Kolomeĭchenko G Iu, Ponomarenko V V
Biokhimiia. 1979 Nov;44(11):2053-7.
Differences in the dehydration rates of tetrahydro-1,4-benzdiazepine-2-one in the liver, kidney and adrenals of mice, rats and guinea pigs have been revealed. It has been found that the enzyme catalyzing the substrate conversion into its dihydroderivative is localized in the microsomal and soluble fractions of the organs tested and has a pH optimum of 9,0. The enzyme activity depends on the concentation of phosphate ions in the incubation medium.
已揭示了小鼠、大鼠和豚鼠的肝脏、肾脏和肾上腺中四氢-1,4-苯二氮䓬-2-酮脱水速率的差异。已发现催化底物转化为其二氢衍生物的酶定位于所测试器官的微粒体和可溶性部分，最适pH为9.0。酶活性取决于孵育介质中磷酸根离子的浓度。
