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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Yamato C, Takahashi T, Fujita T

Xenobiotica. 1976 May;6(5):295-306. doi: 10.3109/00498257609151641.

After oral administration of (14C) trazodone HCl (4 mg/kg) to rabbits, the blood level of radioactivity shows a peak at 3 h; unchanged trazodone concentration in brain is higher than that in plasma at 3 h after dosage. 29 The metabolic fate of trazodone in rabbits is different from that in rats and a new, basic metabolite is present in rabbit liver, brain, plasma and urine. 3. The concentration pattern in blood of humans given a single dosage (50 mg) of trazodone HCl is similar to that in rabbits rather than that in rats. 4. The rate of metabolism of trazodone by liver microsomes from mice is approximately 1-5 times higher than that with rat or rabbit liver microsomes.

给兔子口服(14C)盐酸曲唑酮(4毫克/千克)后，放射性血药浓度在3小时达到峰值；给药后3小时，脑中未变化的曲唑酮浓度高于血浆中的浓度。29曲唑酮在兔子体内的代谢命运与在大鼠体内不同，一种新的碱性代谢物存在于兔肝、脑、血浆和尿液中。3. 给予单次剂量(50毫克)盐酸曲唑酮的人体血液中的浓度模式与兔子相似，而非与大鼠相似。4. 小鼠肝微粒体对曲唑酮的代谢速率比大鼠或兔肝微粒体高约1 - 5倍。

Yamato C, Takahashi T, Fujita T

Xenobiotica. 1976 May;6(5):295-306. doi: 10.3109/00498257609151641.

After oral administration of (14C) trazodone HCl (4 mg/kg) to rabbits, the blood level of radioactivity shows a peak at 3 h; unchanged trazodone concentration in brain is higher than that in plasma at 3 h after dosage. 29 The metabolic fate of trazodone in rabbits is different from that in rats and a new, basic metabolite is present in rabbit liver, brain, plasma and urine. 3. The concentration pattern in blood of humans given a single dosage (50 mg) of trazodone HCl is similar to that in rabbits rather than that in rats. 4. The rate of metabolism of trazodone by liver microsomes from mice is approximately 1-5 times higher than that with rat or rabbit liver microsomes.

给兔子口服(14C)盐酸曲唑酮(4毫克/千克)后，放射性血药浓度在3小时达到峰值；给药后3小时，脑中未变化的曲唑酮浓度高于血浆中的浓度。29曲唑酮在兔子体内的代谢命运与在大鼠体内不同，一种新的碱性代谢物存在于兔肝、脑、血浆和尿液中。3. 给予单次剂量(50毫克)盐酸曲唑酮的人体血液中的浓度模式与兔子相似，而非与大鼠相似。4. 小鼠肝微粒体对曲唑酮的代谢速率比大鼠或兔肝微粒体高约1 - 5倍。