Butler J, Rydell N W, Balazs E A
Acta Vet Scand. 1970;11(2):139-55. doi: 10.1186/BF03547976.
Twelve horses with traumatic arthritis were treated with intraarticular injection of hyaluronic acid mixed with cortisone and the results compared with 6 horses treated only with cortisone. There was a significantly better improvement in the group injected with a mixture of hyaluronic acid and cortisone. Further studies have given the same results in traumatic arthritis in horses if hyaluronic acid alone is injected. After injection of hyaluronic acid a large number of granulated monocytes appeared in the synovial fluid, but no inflammatory signs were observed. It is possible that this macrophage invasion is instrumental in producing improvement in the condition of the joint. The injected hyaluronic acid may also adhere to the surface of articular cartilage producing an “clastic cushion” protecting the cartilage surface. Experimental mechanical damage was also inflicted on the surface of articular cartilage in dogs and monkeys, and smoother healing was achieved if hyaluronic acid was injected into the joints after the damage. Injections of hyaluronic acid seem to be of value in treating traumatic arthritis or similar conditions.
对12匹患创伤性关节炎的马进行关节腔内注射透明质酸与可的松的混合液治疗，并将结果与仅用可的松治疗的6匹马进行比较。注射透明质酸与可的松混合液的组改善效果明显更好。进一步研究表明，在马的创伤性关节炎中，单独注射透明质酸也会得到相同结果。注射透明质酸后，滑液中出现大量颗粒状单核细胞，但未观察到炎症迹象。这种巨噬细胞浸润可能有助于改善关节状况。注入的透明质酸也可能附着在关节软骨表面，形成“弹性垫”，保护软骨表面。还对狗和猴子的关节软骨表面造成实验性机械损伤，损伤后向关节内注射透明质酸可实现更平滑的愈合。注射透明质酸似乎对治疗创伤性关节炎或类似病症有价值。
