自体条件血浆与透明质酸加皮质类固醇治疗犬肘关节骨关节炎的前瞻性试验。
Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs.
作者信息
Franklin Samuel P, Cook James L
机构信息
Comparative Orthopaedic Laboratory, College of Veterinary Medicine, University of Missouri - Columbia, 379 East Campus Drive, Columbia, Missouri 65211, USA.
出版信息
Can Vet J. 2013 Sep;54(9):881-4.
Abstract
This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex). An investigator blinded to the treatments graded lameness (0-4) before and 6 months after a single injection with either HA + S or ACP. Clients were blinded to treatment and completed a validated survey before and 1, 6, 12, and 24 weeks after injection. Ten dogs (5 per group) completed all parts of the study. Pre-treatment lameness grades were 1.2 ± 0.97 for HA + S and 1.8 ± 1.1 for ACP and were not different between groups. Post-treatment lameness grades were 0.4 ± 0.55 for HA + S and 0.8 ± 0.64 for ACP with significant (P < 0.05) improvement with either treatment but without differences between groups. Client-based assessments demonstrated improvements in activity, lameness, and pain with HA + S and ACP. These data suggest that both treatments have beneficial effects for dogs with bilateral elbow OA.
摘要
这项前瞻性、随机、双盲试验比较了接受透明质酸加甲基强的松龙（HA + S）或自体条件血浆（ACP(®); Arthrex公司）治疗的双侧肘关节骨关节炎（OA）犬的治疗效果。一名对治疗方案不知情的研究人员在单次注射HA + S或ACP之前及之后6个月对跛行程度进行评分（0 - 4级）。客户对治疗方案不知情，并在注射前、注射后1周、6周、12周和24周完成一份经过验证的调查问卷。10只犬（每组5只）完成了研究的所有部分。HA + S组治疗前的跛行评分为1.2±0.97，ACP组为1.8±1.1，两组之间无差异。治疗后，HA + S组的跛行评分为0.4±0.55，ACP组为0.8±0.64，两种治疗方法均有显著改善（P < 0.05），但两组之间无差异。基于客户的评估显示，HA + S和ACP治疗后犬的活动能力、跛行程度和疼痛均有所改善。这些数据表明，两种治疗方法对双侧肘关节OA犬均有有益效果。
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