标准赛马掌指关节和腕中关节滑液中透明质酸的周转率。
Hyaluronan turnover in the synovial fluid in metacarpophalangeal--and middle carpal joints in standardbred horses.
作者信息
Lindholm A, Ronéus B, Lindblad G, Jones B
机构信息
Department of Medicine and Surgery, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden.
出版信息
Acta Vet Scand. 1996;37(2):147-51. doi: 10.1186/BF03548107.
Abstract
The biological turnover of hyaluronan (sodium hyaluronate) of different molecular weights (0.6 x 10(6) and 2.5 x 10(6) Daltons) was studied in the synovial fluid of the middle carpal and metacarpophalangeal joints of 6 clinically healthy Standardbred horses. The hyaluronan was radioactively labelled with 14C. The biological half-life (t1/2) was calculated from repeated synovial samples after injection of the labelled hyaluronan. The mean t1/2 in the metacarpophalangeal joints was 9.7 h for low molecular weight hyaluronan and 8.9 h for high molecular weight hyaluronan and in the middle carpal joints 16.0 h and 12.5 h respectively. These was no significant difference in turnover of the different molecular weights of hyaluronan.
摘要
在6匹临床健康的标准赛马的腕中关节和掌指关节滑液中，研究了不同分子量（0.6×10⁶和2.5×10⁶道尔顿）的透明质酸（透明质酸钠）的生物转换。透明质酸用¹⁴C进行放射性标记。在注射标记的透明质酸后，根据重复采集的滑液样本计算生物半衰期（t1/2）。掌指关节中，低分子量透明质酸的平均t1/2为9.7小时，高分子量透明质酸为8.9小时；腕中关节中，分别为16.0小时和12.5小时。不同分子量透明质酸的转换没有显著差异。
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