衰老过程中尾状核内叶酸和二氢叶酸还原酶的“原位”变化
"In situ" variation of folic acid and dihydrofolate reductase in the caudate nucleus in the ageing process.
作者信息
Diculescu I, Onicescu D
出版信息
J Hirnforsch. 1979;20(6):667-70.
PMID:546986
Abstract
In bovine caudate nucleus of young animal, a folic acid-positive reaction was found in the perikarya and in the neuroglia in parallel with a high dihydrofolate reductase activity in the nerve cells. In old animals, folic acid increased in neurons, neuroglia and some nerve cell processes; the folate enzyme was markedly decreased in neurons and increased neuroglia NADH2-cytochrom-C-reductase activity was strongly positive in nerve cells in young and old animals.
摘要
在幼年动物的牛尾状核中，在神经细胞的核周体和神经胶质中发现了叶酸阳性反应，同时神经细胞中具有高的二氢叶酸还原酶活性。在老年动物中，神经元、神经胶质和一些神经细胞突起中的叶酸增加；神经元中的叶酸酶明显减少，神经胶质中增加，烟酰胺腺嘌呤二核苷酸还原酶-细胞色素C还原酶活性在幼年和老年动物的神经细胞中均呈强阳性。
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