大鼠和小鼠体内2,4-甲苯二胺代谢情况的比较。
Comparison of the metabolism of 2,4-toluenediamine in rats and mice.
作者信息
Grantham P H, Mohan L, Benjamin T, Roller P P, Miller J R, Weisburger E K
出版信息
J Environ Pathol Toxicol. 1979 Dec;3(1-2):149-66.
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than in rats. However, the feces of rats accounted for a greater percentage of the dose in rats than in mice. The distribution of metabolites in tissues were considerably lower in mice than in rats. The major urinary metabolites observed in the rat were 4-acetylamino-2-aminotoluene, 2,4-diacetylaminotoluene, 4-acetylamino-2-aminobenzoic acid. The major metabolites in the mice were 4-acetylamino-2-aminobenzoic acid, 4-acetylamino-2-aminotoluene and 2,4-diacetylaminobenzoic acid.
对2,4-甲苯二胺（TDA）在大鼠和小鼠体内的排泄、分布及代谢情况进行了比较。与大鼠相比，小鼠将TDA代谢产物排泄到尿液中的速度更快且更彻底。然而，大鼠粪便中占剂量的百分比高于小鼠。小鼠体内组织中代谢产物的分布比大鼠低得多。在大鼠中观察到的主要尿液代谢产物为4-乙酰氨基-2-氨基甲苯、2,4-二乙酰氨基甲苯、4-乙酰氨基-2-氨基苯甲酸。小鼠中的主要代谢产物为4-乙酰氨基-2-氨基苯甲酸、4-乙酰氨基-2-氨基甲苯和2,4-二乙酰氨基苯甲酸。
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