Krieglstein G K
Klin Monbl Augenheilkd. 1979 Nov;175(5):627-33.
In 22 open-angle glaucoma patients a total of 39 eyes were treated with Timolol 0.25% twice daily for an average period of 12.6 months. The relative intraocular pressure decrease at the beginning of the study was 47% of the untreated pressure level. This initial response declined to a 23% pressure decrease at the end of the study. In 8 eyes treatment had to be discontinued because of insufficient pressure control and in one patient because of subjective intolerance. In two patients (4 eyes) a complete loss of response of Timolol therapy was observed. The phenomenon of slowly diminishing drug effectiveness was not related to the untreated pressure levels in the patients covered by this study. In 5 eyes there was evidence of a rebound effect after discontinuation of Timolol therapy.
在22例开角型青光眼患者中，共39只眼接受了0.25%噻吗洛尔治疗，每日两次，平均治疗时间为12.6个月。研究开始时，相对眼压降低幅度为未治疗时眼压水平的47%。这种初始反应在研究结束时降至眼压降低23%。8只眼因眼压控制不足而不得不停止治疗，1例患者因主观不耐受而停药。在2例患者（4只眼）中观察到噻吗洛尔治疗完全失去反应。本研究涵盖的患者中，药物疗效缓慢降低的现象与未治疗时的眼压水平无关。5只眼有证据表明在噻吗洛尔治疗停药后出现了反跳效应。
