Hotz J, Goebell H
Klin Wochenschr. 1979 Dec 3;57(23):1265-71. doi: 10.1007/BF01492982.
The inhibitory action of both calcitonin (CT) and glucagon (GK) on human pancreatic secretion has been evaluated in detail. The reduction of enzyme secretion expressed as percentage corresponded to 60--80% of the initial values in response to both CT and GK when the hormones were given as single infusions during background stimulation with secretin or with secretin plus cholecystokinin-pancreozymin (CCK-PZ). After withdrawal of GK-infusion the return to normal values of enzyme secretion was distinctly faster than after CT, thus reflecting a more rapid degradation of circulating GK than of CT. In the presence of stimulation with secretin plus CCK-PZ, the combined administration of CT and GK did not enhance the inhibitory actions of CT and GK. Fluid and bicarbonate secretions were not affected by either CT or GK. The results suggest that CT and GK inhibit human pancreatic enzyme secretion by similar modes of action. Therefore, the combined administration of both CT and GK does not offer a reasonable approach to the treatment of acute pancreatitis.
降钙素（CT）和胰高血糖素（GK）对人体胰腺分泌的抑制作用已得到详细评估。当在促胰液素或促胰液素加胆囊收缩素 - 胰酶泌素（CCK - PZ）背景刺激下单次输注这些激素时，以百分比表示的酶分泌减少量相当于初始值的60 - 80%，这是对CT和GK两者的反应。停止输注GK后，酶分泌恢复到正常水平的速度明显快于停止输注CT后，这表明循环中的GK比CT降解得更快。在促胰液素加CCK - PZ刺激存在的情况下，CT和GK联合给药并未增强CT和GK的抑制作用。液体和碳酸氢盐分泌不受CT或GK的影响。结果表明，CT和GK通过相似的作用方式抑制人体胰腺酶分泌。因此，CT和GK联合给药并不是治疗急性胰腺炎的合理方法。
