Gray G D, Mickelson M M
Immunology. 1970 Sep;19(3):417-28.
The immunosuppressive specificity of adamantoyl cytarabine [1-β-D-arabinofuranosylcytosine 5′-(1-adamantanecarboxylate), ADOCA] has been studied in rats. Previously, ADOCA had been shown to prolong skin allograft survival in both rats and mice, and to suppress the graft--host reaction and haemagglutinin response of mice. In the current experiments, although ADOCA was capable of markedly suppressing the response of rats to bovine serum albumin, ADOCA could not suppress the primary haemagglutinin response to sheep erythrocytes, nor the agglutinin response to bacterial flagellin. In comparing ADOCA with other immunosuppressants, with one possible exception, ADOCA appears to possess unique immunosuppressive specificity in rats. The major site of ADOCA immunosuppression in the rat was suggested to be the thymus-dependent bone marrow-derived lymphocyte.
在大鼠中研究了金刚烷酰阿糖胞苷[1-β-D-阿拉伯呋喃糖基胞嘧啶5′-(1-金刚烷羧酸酯)，ADOCA]的免疫抑制特异性。此前，已证明ADOCA可延长大鼠和小鼠皮肤同种异体移植的存活时间，并抑制小鼠的移植物抗宿主反应和血凝素反应。在当前实验中，尽管ADOCA能够显著抑制大鼠对牛血清白蛋白的反应，但ADOCA不能抑制对绵羊红细胞的初次血凝素反应，也不能抑制对细菌鞭毛蛋白的凝集素反应。在将ADOCA与其他免疫抑制剂进行比较时，除了一个可能的例外，ADOCA在大鼠中似乎具有独特的免疫抑制特异性。大鼠中ADOCA免疫抑制的主要部位被认为是胸腺依赖性骨髓来源的淋巴细胞。
