新生大鼠的甘油代谢
Glycerol metabolism in the neonatal rat.
作者信息
Vernon R G, Walker D G
出版信息
Biochem J. 1970 Jul;118(3):531-6. doi: 10.1042/bj1180531.
Abstract
- The possible role of glycerol as a precursor in neonatal gluconeogenesis in the rat was investigated by recording the activities of glycerol kinase and l-glycerol 3-phosphate dehydrogenase in the liver, kidney and other tissues around birth and during the neonatal period. 2. Blood glycerol concentrations in the neonatal rat are high. 3. There is a marked increase after birth in the ability of both liver and kidney slices to convert glycerol into glucose plus glycogen that correlates with the increase in glycerol kinase activity. 4. High hepatic and renal l-glycerol 3-phosphate dehydrogenase activities are also found in the neonatal period. 5. The marked capacity for neonatal gluconeogenesis from glycerol thus demonstrated and the role of glycerol kinase in its control are discussed.
摘要
- 通过记录出生前后及新生期大鼠肝脏、肾脏和其他组织中甘油激酶和L-甘油-3-磷酸脱氢酶的活性，研究了甘油作为大鼠新生期糖异生作用前体的可能作用。2. 新生大鼠的血液甘油浓度很高。3. 出生后，肝脏和肾脏切片将甘油转化为葡萄糖和糖原的能力显著增加，这与甘油激酶活性的增加相关。4. 在新生期也发现肝脏和肾脏中L-甘油-3-磷酸脱氢酶活性很高。5. 讨论了由此证明的新生大鼠从甘油进行糖异生的显著能力以及甘油激酶在其调控中的作用。
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