Ghussen F, Stock W, Bongartz R
Res Exp Med (Berl). 1979 Dec;176(2):87-95. doi: 10.1007/BF01851746.
In experiments in dogs rubber tourniquets were tied around both hind limbs as close to the hip as possible, and a 4-h acute ischemia was induced. With the removal of the tourniquets the tourniquet-shock was produced. In a control group no therapy of the shock was carried out. The animals were observed for 6 h. In a second group, methylprednisolone 40 mg/kg BW was given immediately after revascularisation. In a third group, methylprednisolone 40 mg/kg was given prophylactically 10 min before the tourniquets were applied and therapeutically as soon as the blood circulation was opened. Hemodynamic parameters and renal function were measured to examine the pharmacological effect of methylprednisolone in acute tourniquet-shock. The mortality rate in the control group was 90%, while it was 50% by therapeutic and/or prophylactic application of methylprednisolone. The prophylactic application of methylprednisolone reduced development of metabolic acidosis, hemoconcentration, and hyperkaliemia during ischemia so that a mitigated course of shock was observed.
在犬类实验中，将橡胶止血带尽可能靠近髋部绑在双后肢上，诱导4小时急性缺血。松开止血带后引发止血带休克。对照组不对休克进行治疗。对动物观察6小时。第二组在血管再通后立即给予甲泼尼龙40mg/kg体重。第三组在应用止血带前10分钟预防性给予甲泼尼龙40mg/kg，并在血液循环恢复后立即进行治疗。测量血流动力学参数和肾功能，以研究甲泼尼龙在急性止血带休克中的药理作用。对照组的死亡率为90%，而通过甲泼尼龙的治疗性和/或预防性应用，死亡率为50%。甲泼尼龙的预防性应用减少了缺血期间代谢性酸中毒、血液浓缩和高钾血症的发生，从而观察到休克过程有所减轻。
