Bossart R, Henry K, Booth C C, Doe W F
Gut. 1975 Jan;16(1):18-22. doi: 10.1136/gut.16.1.18.
Intestinal biopsies from 146 patients with adult coeliac disease and 13 patients with intestinal villous atrophy of different aetiology were assessed for the presence of subepithelial collagen and compared with a group of 20 control subjects. Subepithelial collagen was a common and non-specific finding observed in intestinal biopsies from patients suffering from adult coeliac disease (36%) and tropical sprue. In adult coeliac disease the described subepithelial changes usually regress following treatment, though marked subepithelial collagen deposition may indicate a poor prognosis. The study showed that the presence of marked subepithelial collagen in a flat jejunal biopsy does not define a separate clinical entity.
对146例成人乳糜泻患者和13例不同病因的肠道绒毛萎缩患者的肠道活检样本进行评估，以检测上皮下胶原的存在情况，并与20名对照受试者组成的小组进行比较。上皮下胶原是在成人乳糜泻患者（36%）和热带口炎性腹泻患者的肠道活检中观察到的常见非特异性表现。在成人乳糜泻中，上述上皮下改变通常在治疗后消退，不过明显的上皮下胶原沉积可能预示预后不良。该研究表明，空肠活检显示存在明显的上皮下胶原并不能定义一个单独的临床实体。
