分枝杆菌素P和S生物合成的早期步骤。
Early steps in the biosynthesis of mycobactins P and S.
作者信息
Tateson J E
出版信息
Biochem J. 1970 Aug;118(5):747-53. doi: 10.1042/bj1180747.
Abstract
- Lysine is readily incorporated into mycobactins P and S. Incorporation is into the hydroxamic acid moieties only and is equal in the mycobactic acid and cobactin portions of the molecule. 2. 2-Amino-6-hydroxyaminohexanoic acid is not taken up by cells of Mycobacterium phlei and is not detectable in extracts of cells actively synthesizing mycobactin. 3. The most abundant material derived from lysine that can be detected in such cell extracts is an N(6)-acyl-lysine. Cells grown in the presence of iron contain markedly less of this material than do those grown under conditions of iron deficiency. 4. When added to growing cultures of M. phlei the N(6)-acyl-lysine is readily incorporated into mycobactin. 5. The hydroxy acid of cobactin P is derivable from propionate.
摘要
- 赖氨酸很容易掺入分枝杆菌素P和S中。仅掺入异羟肟酸部分，且在分子的分枝菌酸和钴胺素部分掺入量相等。2. 2-氨基-6-羟基氨基己酸不被草分枝杆菌细胞摄取，在活跃合成分枝杆菌素的细胞提取物中也检测不到。3. 在此类细胞提取物中可检测到的源自赖氨酸的最丰富物质是N(6)-酰基赖氨酸。在铁存在下生长的细胞中这种物质的含量明显低于在缺铁条件下生长的细胞。4. 当添加到草分枝杆菌的生长培养物中时，N(6)-酰基赖氨酸很容易掺入分枝杆菌素中。5. 钴胺素P的羟酸可源自丙酸。
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