黄曲霉毒素B1对家兔呼吸及氧化磷酸化的影响。II. 心脏和肾脏线粒体的研究
[Effect of aflatoxin B 1 on respiration and oxidative phosphorylation in the rabbit. II. Research on cardiac and renal mitochondria].
作者信息
Borgatti A R, Trigari G
出版信息
Boll Soc Ital Biol Sper. 1979 Nov 15;55(21):2253-9.
The effect of various concentrations of aflatoxin B1 (AB1) is studied "in vitro" on heart (HM) and kidney mitochondria of rabbit (KM). AB1 inhibits (4 x 10(-4)M) the respiratory rate up to a maximum 50-35% in HM and 28-35% in KM by glutamate and succinate as substrates respectively, but it does not uncouple oxidative phosphorylation nor does it inhibit site III (ascorbate + TMPD). The inhibited site appears to be between cytochromes b and c (c1). AB1 seems to be easily transported across heart mitochondrial membrane. The relevance of these findings to liver cell necrosis promoted by aflatoxin is discussed.
研究了不同浓度黄曲霉毒素B1（AB1）“体外”对兔心脏线粒体（HM）和肾脏线粒体（KM）的影响。以谷氨酸和琥珀酸为底物时，AB1（4×10⁻⁴M）分别使HM的呼吸速率最大抑制50 - 35%，使KM的呼吸速率最大抑制28 - 35%，但它不会使氧化磷酸化解偶联，也不抑制位点III（抗坏血酸 + TMPD）。受抑制的位点似乎在细胞色素b和c（c1）之间。AB1似乎很容易穿过心脏线粒体膜。讨论了这些发现与黄曲霉毒素引发的肝细胞坏死的相关性。
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