Tsyganiĭ A A, Medvinskaia N A
Farmakol Toksikol. 1984 Jul-Aug;47(4):30-3.
Nitrous oxide was discovered to have different effects on oxidative phosphorylation of heart, liver, kidney and brain mitochondria. The most demonstrable changes were found in the myocardium and liver. An increase in the anesthetic concentration provoked a more considerable inhibition of the rate of oxygen consumption in different metabolic states and of the phosphorylation rate of liver and myocardial mitochondria. High doses of nitrous oxide were found to inhibit ATPase activity of myocardial actomyosin. The action of the anesthetic on the brain manifested in the inhibition of the phosphorylation rate, that on the kidneys in the increased rate of free oxidation.
人们发现一氧化二氮对心脏、肝脏、肾脏和脑线粒体的氧化磷酸化有不同影响。最明显的变化出现在心肌和肝脏中。麻醉剂浓度的增加在不同代谢状态下对氧消耗速率以及肝脏和心肌线粒体的磷酸化速率产生了更显著的抑制作用。发现高剂量的一氧化二氮会抑制心肌肌动球蛋白的ATP酶活性。麻醉剂对大脑的作用表现为磷酸化速率的抑制，对肾脏的作用表现为自由氧化速率的增加。
