2,3,7,8-四氯二苯并呋喃（TCDF）对豚鼠免疫系统的影响。

Effects of 2,3,7,8-tetrachlorodibenzofuran (TCDF) on the immune system in guinea pigs.

作者信息

Luster M I, Faith R E, Lawson L D

出版信息

Drug Chem Toxicol. 1979;2(1-2):49-60. doi: 10.3109/01480547908993181.

Abstract

The effects of TCDF exposure on the immune system were investigated in Hartley guinea pigs. TCDF was administered by gavage at doses of 0.05, 0.17, 0.5 or 1.0 microgram/kg body weight once weekly for six weeks. Thymus/body weight ratios were suppressed in the higher dosage groups. Parameters of cell-mediated and humoral immune function were investigated. TCDF modestly suppressed cell-mediated immune function and had slight effects on humoral-mediated functions. TCDF immunosuppression appears similar to that induced following exposure to TCDD.

摘要

在哈特利豚鼠中研究了2,3,7,8-四氯二苯并呋喃（TCDF）暴露对免疫系统的影响。TCDF通过灌胃给药，剂量为0.05、0.17、0.5或1.0微克/千克体重，每周一次，共六周。较高剂量组的胸腺/体重比受到抑制。对细胞介导和体液免疫功能的参数进行了研究。TCDF适度抑制细胞介导的免疫功能，对体液介导的功能有轻微影响。TCDF诱导的免疫抑制似乎与2,3,7,8-四氯二苯并二噁英（TCDD）暴露后诱导的免疫抑制相似。