Silkworth J B, Loose L D
Environ Health Perspect. 1981 Jun;39:105-28. doi: 10.1289/ehp.8139105.
Although it has been established that environmental contaminants can alter immune function, the mechanisms of action have yet to be determined. This paper reviews the effects of hydrocarbon environmental contaminants on lymphocyte function and presents an approach which may serve to delineate the mechanisms of action. The approach is based on the use of the developmental phases of an immune response and assays which can be used for their functional assessment. Possible interactions between environmental contaminants and lymphocyte function and factors which must be considered in the evaluation of immune status are discussed. In addition, a study on the influence of the chronic exposure to two polyhalogenated hydrocarbons, PCB and HCB, on several parameters of lymphocyte function in mice is presented.
尽管已经确定环境污染物可改变免疫功能,但其作用机制尚未明确。本文综述了碳氢化合物环境污染物对淋巴细胞功能的影响,并提出了一种可能有助于阐明其作用机制的方法。该方法基于免疫反应的发育阶段以及可用于其功能评估的检测方法。文中讨论了环境污染物与淋巴细胞功能之间可能的相互作用以及在评估免疫状态时必须考虑的因素。此外,还介绍了一项关于长期暴露于两种多卤代烃(多氯联苯和六氯苯)对小鼠淋巴细胞功能若干参数影响的研究。