Cassano G B, Maggini C, Longo E
Encephale. 1979;5(5 Suppl):449-58.
The definition of chronic depression necessarily calls for a review of the concept of recovery which in psychopathology is not clearly and univocally defined. The percentage of chronic evolution among depressive patients either as a persistence of depressive symptoms or as an impairment of social and professional role, ranges from 12 to 15%. Chronic depression raises psychopathologic and nosographic problems as well as clinical ones. In fact chronic depressives are often not correctly diagnosed, inadequately treated and destined to be affected by an over increasing inability. The chronic evolution of depression may result as a concurrence of several factors: a neurotic personality, an inadequate antidepressant maintenance treatment, an inappropriated use of minor tranquillizers as the only treatment. The occurrence of physical impairement, the continuous nature of depression and the resistance of antidepressant treatment may be also considered. Moreover the psychodynamic mechanisms aroused by the depressive experience and the secondary advantages of the illness may plan an effective role maintaining depressive symptomatology.
慢性抑郁症的定义必然需要回顾康复的概念,而在精神病理学中,康复的概念并没有得到清晰且明确的界定。在抑郁症患者中,以抑郁症状持续存在或社会及职业角色受损为表现的慢性病程比例在12%至15%之间。慢性抑郁症引发了精神病理学、疾病分类学以及临床方面的问题。事实上,慢性抑郁症患者常常得不到正确的诊断、治疗不充分,而且注定会受到日益严重的功能障碍的影响。抑郁症的慢性病程可能是多种因素共同作用的结果:神经质人格、抗抑郁维持治疗不当、仅将小剂量镇静剂作为唯一治疗方法的不恰当使用。身体损伤的发生、抑郁症的持续性以及抗抑郁治疗的耐药性也可能是相关因素。此外,抑郁经历引发的心理动力学机制以及疾病的继发性获益可能在维持抑郁症状方面发挥有效作用。