注入实验大鼠足垫的可溶性抗原的全身分布。
The systemic distribution of soluble antigen injected into the footpad of the laboratory rat.
作者信息
Tilney N L
出版信息
Immunology. 1970 Jul;19(1):181-4.
Abstract
Injection into the hind footpad of the rat combines intradermal and subcutaneous routes. Material injected into the dermis of the sole is rapidly distributed by the lymphatics to several lymph node groups and enters the bloodstream principally with the thoracic duct lymph. The diffuse character of the lymphatic drainage of this site is emphasized. Material in the subcutaneous tissues gradually enters the systemic circulation and is filtered through various organs. Antigen injected into the footpad can elicit both effective delayed hypersensitivity and humoral host responses.
摘要
将物质注射到大鼠后足垫结合了皮内和皮下途径。注入足底真皮的物质会通过淋巴管迅速分布到几个淋巴结群，并主要随胸导管淋巴进入血液循环。强调了该部位淋巴引流的弥散性。皮下组织中的物质逐渐进入体循环并通过各种器官进行过滤。注入足垫的抗原可引发有效的迟发型超敏反应和体液宿主反应。
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本文引用的文献
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THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT.大鼠淋巴细胞的再循环途径
Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:257-82. doi: 10.1098/rspb.1964.0001.
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Lymphatico-venous communications in the albino rat.白化大鼠的淋巴管 - 静脉交通支
J Anat. 1959 Jul;93(Pt 3):380-3.
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Formation of specific antibodies and gamma-globulin in vitro; a study of the synthetic ability of various tissues from rabbits immunized by different methods.体外特异性抗体和γ球蛋白的形成；对用不同方法免疫的家兔各种组织合成能力的研究。
Biochem J. 1958 Feb;68(2):252-61. doi: 10.1042/bj0680252.
6
Studies on the sensitization of animals with simple chemical compounds. XI. The fate of labeled picryl chloride and dinitrochlorobenzene after sensitizing injections.用简单化合物使动物致敏的研究。十一、致敏注射后标记的氯化苦基和二硝基氯苯的命运。
J Exp Med. 1969 Jan 1;129(1):81-102. doi: 10.1084/jem.129.1.81.
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