不同分枝杆菌14C标记纯化蛋白衍生物的比较研究。II. 致敏豚鼠的皮肤交叉反应性。
Comparative study of 14C-labeled purified protein derivative from various mycobacteria. II. Skin cross-reactivity in sensitized guinea pigs.
作者信息
Landi S, Held H R
出版信息
Appl Microbiol. 1970 Nov;20(5):704-9. doi: 10.1128/am.20.5.704-709.1970.
A study on skin cross-reactivity between stabilized (14)C-labeled mycobacterial antigens, namely tuberculin purified protein derivative (PPD; from Mycobacterium tuberculosis), PPD-A (M. avium), PPD-Y (M. kansasii), PPD-G (M. scrofulaceum), PPD-B (M. intracellulare), and PPD-F (M. fortuitum), has been carried out in groups of guinea pigs sensitized with one of the following heat-killed mycobacteria: M. tuberculosis, M. avium, M. kansasii, M. scrofulaceum, M. intracellulare, or M. fortuitum. For each type of sensitization, the average response for the corresponding PPD antigen was higher than the average response for any of the other antigens. However, the responses to the heterologous PPD antigens were not necessarily significantly different among themselves, and the significant differences of the heterologous PPD antigens were distributed differently according to the type of sensitization. Therefore, (14)C-PPD antigens skin cross-reacted in guinea pigs essentially in the same manner as reported by others for nonradioactive PPD antigens.
一项关于稳定的（14）C标记分枝杆菌抗原之间皮肤交叉反应性的研究已经在豚鼠群体中开展，这些抗原包括结核菌素纯化蛋白衍生物（PPD；来自结核分枝杆菌）、PPD-A（鸟分枝杆菌）、PPD-Y（堪萨斯分枝杆菌）、PPD-G（瘰疬分枝杆菌）、PPD-B（胞内分枝杆菌）和PPD-F（偶然分枝杆菌），这些豚鼠群体用以下热灭活分枝杆菌之一进行致敏：结核分枝杆菌、鸟分枝杆菌、堪萨斯分枝杆菌、瘰疬分枝杆菌、胞内分枝杆菌或偶然分枝杆菌。对于每种致敏类型，相应PPD抗原的平均反应高于任何其他抗原的平均反应。然而，对异源PPD抗原的反应彼此之间不一定有显著差异，并且异源PPD抗原的显著差异根据致敏类型的不同而不同。因此，（14）C-PPD抗原在豚鼠中的皮肤交叉反应基本上与其他人报道的非放射性PPD抗原相同。
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