Garland W A, Min B H
J Chromatogr. 1979 Apr 21;172:279-86. doi: 10.1016/s0021-9673(00)90963-4.
Our previously reported gas chromatographic--mass spectrometric assay for clonazepam using positive ion chemical ionization has been modified to employ negative ion chemical ionization. The sensitivity using this technique (less than 0.1 ng/ml) is approximately twenty times better than the positive ion chemical ionization procedure with similar precision. The method was used to determine the clonazepam plasma concentration in one human for 96 h following a single 2-mg dose of clonazepam.
我们之前报道的使用正离子化学电离的氯硝西泮气相色谱-质谱分析法已被修改为采用负离子化学电离。使用该技术的灵敏度（低于0.1 ng/ml）比具有相似精密度的正离子化学电离方法约高20倍。该方法用于测定一名人类单次服用2毫克氯硝西泮后96小时内的氯硝西泮血浆浓度。
