蛙皮素对麻醉犬胰岛素分泌的影响。
The effects of caerulein on insulin secretion in anaesthetized dogs.
作者信息
Bertaccini G, De Caro G, Melchiorri P
出版信息
Br J Pharmacol. 1970 Sep;40(1):78-85. doi: 10.1111/j.1476-5381.1970.tb10612.x.
Abstract
- Insulin concentration changes in pancreatico-duodenal venous plasma were studied in anaesthetized dogs injected with caerulein.2. Rises in insulin concentration were elicited by rapid intravenous injection of caerulein, as well as by intravenous infusion. Threshold doses were 10 ng/kg and 0.5-1 (ng/kg)/min respectively.3. At the highest dose used (500 ng/kg by rapid intravenous injection and (25 ng/kg)/min by intravenous infusion) the increase in immuno-reactive insulin release was approximately 7 to 9 times the base levels.4. Adrenalectomy potentiated the effects of intravenous infusion of caerulein.5. On a molar basis, caerulein was 2-3 times as active as pancreozymin.6. It is concluded that caerulein is a potent stimulant of pancreatic islets in the dog and that it may be considered as a model peptide, capable of being substituted for pancreozymin in any experiment.7. The mechanism of the insulin stimulating effect of caerulein is discussed. The possibility of a direct "beta-cytotropic" effect of the peptide is suggested.
摘要
对注射了蛙皮素的麻醉犬的胰十二指肠静脉血浆中的胰岛素浓度变化进行了研究。
快速静脉注射蛙皮素以及静脉输注均可引起胰岛素浓度升高。阈值剂量分别为10纳克/千克和0.5 - 1（纳克/千克）/分钟。
在使用的最高剂量下（快速静脉注射500纳克/千克，静脉输注（25纳克/千克）/分钟），免疫反应性胰岛素释放的增加约为基础水平的7至9倍。
肾上腺切除术增强了静脉输注蛙皮素的作用。
以摩尔为基础，蛙皮素的活性是促胰液素的2至3倍。
得出结论，蛙皮素是犬胰岛的一种有效刺激物，并且可以被视为一种模型肽，在任何实验中都能够替代促胰液素。
讨论了蛙皮素刺激胰岛素作用的机制。提出了该肽直接“促β细胞”作用的可能性。
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