Anderson L J, McKeating F J
Immunology. 1970 Dec;19(6):935-43.
To study the zonal response to antigenic stimuli in lymph nodes of the cat, three groups of eight cats received epicutaneous application of oxazolone and inoculations of ovalbumin plus Freund's adjuvant and feline leukaemia virus (FeLV) respectively into the left hind footpads. The changes in the left popliteal nodes were followed histologically and autoradiographically for 14 days. In the oxazolone-treated group, there was an extremely marked proliferation of blast cells in the paracortical areas, maximal on days 3–7; germinal centres developed on day 6; plasma cells did not feature in the response. In the ovalbumin-treated group, the nodes developed a full zonal response, with marked blast cell response in the paracortical areas, formation of prominent germinal centres and a striking plasma cell reaction. In both groups, there was a considerable increase in mast cell numbers in the course of the reactions; the origin of the new mast cells was not clear. The response to FeLV was minimal, despite direct stimulation of the node with high titre virus.
为研究猫淋巴结对抗原刺激的区域反应，三组各八只猫分别接受了恶唑酮的表皮应用，并将卵清蛋白加弗氏佐剂和猫白血病病毒（FeLV）分别接种到左后足垫。对左侧腘窝淋巴结的变化进行了14天的组织学和放射自显影观察。在恶唑酮治疗组中，皮质旁区域的母细胞极度显著增殖，在第3 - 7天达到最大值；生发中心在第6天形成；浆细胞未参与该反应。在卵清蛋白治疗组中，淋巴结产生了完整的区域反应，皮质旁区域有明显的母细胞反应，形成突出的生发中心和显著的浆细胞反应。在两组中，反应过程中肥大细胞数量均有相当大的增加；新肥大细胞的来源尚不清楚。尽管用高滴度病毒直接刺激淋巴结，但对FeLV的反应极小。
