Wilson T S, Fleming W A, Robinson F L, Nicholl B
J Clin Pathol. 1970 Nov;23(8):657-63. doi: 10.1136/jcp.23.8.657.
Two patients on prolonged steroid therapy developed meningitis due to Cryptococcus neoformans. The first responded satisfactorily to treatment with amphotericin B, both initially and again following relapse. The second died shortly after treatment was begun. Pathogenicity studies suggest that the strain isolated from the fatal case was the more virulent. Cryptococcal meningitis probably occurs more often in Britain than is generally appreciated, and this possibility should be remembered when investigating patients with obscure forms of meningitis; if not, then the correct diagnosis may not be made. Attention is drawn to the increasing number of recently reported cases of this disease which have been associated with long-term steroid therapy.
两名长期接受类固醇治疗的患者发生了新型隐球菌性脑膜炎。第一名患者最初接受两性霉素B治疗反应良好，复发后再次治疗也有良好反应。第二名患者在治疗开始后不久死亡。致病性研究表明，从致命病例中分离出的菌株毒性更强。隐球菌性脑膜炎在英国的发生频率可能比普遍认为的要高，在调查患有不明原因脑膜炎的患者时应记住这种可能性；否则，可能无法做出正确诊断。请注意，最近报告的与长期类固醇治疗相关的这种疾病病例数量在增加。
